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Article

Genetic polymorphism related to monocyte-macrophage function is associated with graft-versus-host disease.

Scientific reports - 15 Nov 2017

Hyvärinen Kati, Ritari Jarmo, Koskela Satu, Niittyvuopio Riitta, Nihtinen Anne, Volin Liisa, Gallardo David, Partanen Jukka

Abstract excerpt

Despite detailed human leukocyte antigen (HLA) matching and modern immunosuppressive therapy, severe graft-versus-host disease (GvHD) remains a major hurdle for successful allogeneic hematopoietic stem cell transplantation (HSCT). As the genetic diversity in GvHD complicates the systematic discovery of associated variants across populations, we studied 122 GvHD-associated single nucleotide polymorphisms (SNPs) in...

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Identifiers

PMID: 29142307
DOI: 10.1038/s41598-017-15915-3
PMCID: PMC5688060

Genes

NOD2
TLR9
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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