Article
Genome-wide surveillance of mismatched alleles for graft-versus-host disease in stem cell transplantation.
Blood - 17 Dec 2015
Sato-Otsubo Aiko, Nannya Yasuhito, Kashiwase Koichi, Onizuka Makoto, Azuma Fumihiro, Akatsuka Yoshiki, Ogino Yasuko, Satake Masahiro, Sanada Masashi, Chiba Shigeru, Saji Hiroh, Inoko Hidetoshi, Kennedy Giulia C, Yamamoto Ken, Morishima Satoko, Morishima Yasuo, Kodera Yoshihisa, Sasazuki Takehiko, Ogawa Seishi
Abstract excerpt
Acute graft-versus-host disease (aGVHD) represents one of the major complications in allogeneic stem cell transplantation and is primarily caused by genetic disparity between the donor and recipient. In HLA-matched transplants, the disparity is thought to be determined by loci encoding minor histocompatibility antigens (minor H antigens), which are presented by specific HLA molecules. We performed a genome-wide...
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