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Article

Insulin-degrading enzyme haplotypes affect insulin levels but not dementia risk.

Neuro-degenerative diseases - 1 Jan 2006

Marlowe Lauren, Peila Rita, Benke Kelly Suzanne, Hardy John, White Lon R, Launer Lenore J, Myers Amanda

Abstract excerpt

BACKGROUND: Insulin-degrading enzyme (IDE) polymorphism is hypothesized to regulate insulin levels as well as processes involved in neuronal compromise found in dementia. METHODS: We examined the association of IDE haplotypes with dementia and insulin levels in a single well-characterized cohort of Japanese-American men born between 1900 and 1919 and followed since 1965. In 1991, a fasting insulin was obtained;...

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Source

Identifiers

PMID: 17192720
DOI: 10.1159/000097300

Genes

IDE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Insulin-degrading enzyme haplotypes affect insulin levels but not dementia risk.PMID 17192720Read ↗

Genetic variation in a haplotype block spanning IDE influences Alzheimer disease.Semantic proximity Read ↗

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Association of insulin degrading enzyme gene polymorphisms with Alzheimer's disease: a meta-analysis.Semantic proximity Read ↗

Weak independent association signals between IDE polymorphisms, Alzheimer's disease and cognitive measures.Semantic proximity Read ↗

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High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people.Semantic proximity Read ↗

Concordant Association of Insulin Degrading Enzyme Gene (IDE) Variants with IDE mRNA, Aß, and Alzheimer's DiseaseSemantic proximity Read ↗

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