Weak independent association signals between IDE polymorphisms, Alzheimer's disease and cognitive measures.

doi:10.1016/j.neurobiolaging.2006.03.009

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Article

Weak independent association signals between IDE polymorphisms, Alzheimer's disease and cognitive measures.

Neurobiology of aging - 1 May 2007

Mueller Jakob C, Riemenschneider Matthias, Schoepfer-Wendels Andreas, Gohlke Henning, Konta Lidija, Friedrich Patricia, Illig Thomas, Laws Simon M, Förstl Hans, Kurz Alexander

Abstract excerpt

Functional and genetic studies suggest that insulin-degrading enzyme (IDE) may be a strong functional and positional candidate. As there is a lack of consensus in regards to the level and location of IDE association signals we aimed to clarify these discrepancies through genotyping 28 SNPs in a large case-control collective together with quantitative measures of cognitive ability (MMSE). Four SNPs (rs11187007,...

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PMID: 16675064
DOI: 10.1016/j.neurobiolaging.2006.03.009

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Weak independent association signals between IDE polymorphisms, Alzheimer's disease and cognitive measures.PMID 16675064Read ↗

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