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Article

Sequence variants of IDE are associated with the extent of beta-amyloid deposition in the Alzheimer's disease brain.

Neurobiology of aging - 1 Jun 2005

Blomqvist Mia E-L, Chalmers Katy, Andreasen Niels, Bogdanovic Nenad, Wilcock Gordon K, Cairns Nigel J, Feuk Lars, Brookes Anthony J, Love Seth, Blennow Kaj, Kehoe Patrick G, Prince Jonathan A

Abstract excerpt

Insulin degrading enzyme, encoded by IDE, plays a primary role in the degradation of amyloid beta-protein (A beta), the deposition of which in senile plaques is one of the defining hallmarks of Alzheimer's disease (AD). We recently identified haplotypes in a broad linkage disequilibrium (LD) block encompassing IDE that associate with several AD-related quantitative traits. Here, by examining 32 polymorphic...

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Identifiers

PMID: 15718037
DOI: 10.1016/j.neurobiolaging.2004.07.011

Genes

IDE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sequence variants of IDE are associated with the extent of beta-amyloid deposition in the Alzheimer's disease brain.PMID 15718037Read ↗

Genetic variation in a haplotype block spanning IDE influences Alzheimer disease.Semantic proximity Read ↗

Positive association between risk for late-onset Alzheimer disease and genetic variation in IDE.Semantic proximity Read ↗

Concordant Association of Insulin Degrading Enzyme Gene (IDE) Variants with IDE mRNA, Aß, and Alzheimer's DiseaseSemantic proximity Read ↗

Lack of association of 5 SNPs in the vicinity of the insulin-degrading enzyme (IDE) gene with late-onset Alzheimer's disease.Semantic proximity Read ↗

Sequence variation in the proximity of IDE may impact age at onset of both Parkinson disease and Alzheimer disease.Semantic proximity Read ↗

Disorder-specific effects of polymorphisms at opposing ends of the Insulin Degrading Enzyme gene.Semantic proximity Read ↗

Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease.Semantic proximity Read ↗

Insulin degrading enzyme (IDE) genetic variants and risk of Alzheimer's disease: evidence of effect modification by apolipoprotein E (APOE).Semantic proximity Read ↗

Weak independent association signals between IDE polymorphisms, Alzheimer's disease and cognitive measures.Semantic proximity Read ↗

Insulin-degrading enzyme haplotypes affect insulin levels but not dementia risk.Semantic proximity Read ↗

Association between variants in IDE-KIF11-HHEX and plasma amyloid β levels.Semantic proximity Read ↗

Insulin-degrading enzyme is genetically associated with Alzheimer’s disease in the Finnish populationSemantic proximity Read ↗

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