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Article

Insulin degrading enzyme (IDE) genetic variants and risk of Alzheimer's disease: evidence of effect modification by apolipoprotein E (APOE).

Neuroscience letters - 10 Jul 2003

Edland S D, Wavrant-De Vriesé F, Compton D, Smith G E, Ivnik R, Boeve B F, Tangalos E G, Petersen R C

Abstract excerpt

Insulin degrading enzyme (IDE) is a protease that degrades insulin and the beta-amyloid peptide implicated in Alzheimer's disease (AD). We reexamined data on five previously reported IDE polymorphisms stratifying the analysis by the presence or absence of an apolipoprotein E (APOE) epsilon4 allele. Three IDE variants were associated with AD within epsilon4-negative subjects (genotype exact test P-values < or...

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Source

Identifiers

PMID: 12809979
DOI: 10.1016/s0304-3940(03)00488-9

Genes

IDE
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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