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Article

IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2007

Burchill Matthew A, Yang Jianying, Vogtenhuber Christine, Blazar Bruce R, Farrar Michael A

Abstract excerpt

IL-2(-/-) mice develop autoimmunity despite having relatively normal numbers of regulatory T cells (Tregs). In contrast, we demonstrate that IL-2(-/-) x IL-15(-/-) and IL-2Rbeta(-/-) mice have a significant decrease in Treg numbers. Ectopic expression of foxp3 in a subset of CD4(+) T cells rescued Treg development and prevented autoimmunity in IL-2Rbeta(-/-) mice, suggesting that IL-2Rbeta-dependent signals...

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Identifiers

PMID: 17182565
DOI: 10.4049/jimmunol.178.1.280

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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