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Article

IL-12R beta 2 promotes the development of CD4+CD25+ regulatory T cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2008

Zhao Zhao, Yu Shuo, Fitzgerald Denise C, Elbehi Mohamed, Ciric Bogoljub, Rostami A M, Zhang Guang-Xian

Abstract excerpt

We have previously shown that mice lacking the IL-12-specific receptor subunit beta2 (IL-12Rbeta2) develop more severe experimental autoimmune encephalomyelitis than wild-type (WT) mice. The mechanism underlying this phenomenon is not known; nor is it known whether deficiency of IL-12Rbeta2 impacts other autoimmune disorders similarly. In the present study we demonstrate that IL-12Rbeta2(-/-) mice develop earlier...

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Source

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Identifiers

PMID: 18768841
DOI: 10.4049/jimmunol.181.6.3870
PMCID: PMC2679170

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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