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Article

Human regulatory T-cell development is dictated by Interleukin-2 and -15 expressed in a non-overlapping pattern in the thymus.

Journal of autoimmunity - 1 Jan 2015

Caramalho Iris, Nunes-Silva Vânia, Pires Ana R, Mota Catarina, Pinto Ana I, Nunes-Cabaço Helena, Foxall Russell B, Sousa Ana E

Abstract excerpt

Thymus-derived FOXP3-expressing regulatory T-cells (tTregs) are master orchestrators of physiological and pathological immune responses, thus constituting ideal targets for the treatment of autoimmunity. Despite their clinical importance, the developmental program governing their differentiation in the human thymus remains poorly understood. Here, we investigated the role of common gamma-chain cytokines in human...

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PMID: 25481744
DOI: 10.1016/j.jaut.2014.11.002

Genes

FOXP3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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