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Article

Immune homeostasis enforced by co-localized effector and regulatory T cells.

Nature - 10 Dec 2015

Liu Zhiduo, Gerner Michael Y, Van Panhuys Nicholas, Levine Andrew G, Rudensky Alexander Y, Germain Ronald N

Abstract excerpt

FOXP3(+) regulatory T cells (Treg cells) prevent autoimmunity by limiting the effector activity of T cells that have escaped thymic negative selection or peripheral inactivation. Despite the information available about molecular factors mediating the suppressive function of Treg cells, the relevant cellular events in intact tissues remain largely unexplored, and whether Treg cells prevent activation of...

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Identifiers

PMID: 26605524
DOI: 10.1038/nature16169
PMCID: PMC4702500

Genes

FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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