Article
Preferential T-cell receptor beta-chain variable gene use in myelin basic protein-reactive T-cell clones from patients with multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America - 15 Oct 1991
Kotzin B L, Karuturi S, Chou Y K, Lafferty J, Forrester J M, Better M, Nedwin G E, Offner H, Vandenbark A A
Abstract excerpt
Multiple sclerosis is an autoimmune disease in which T lymphocytes reactive to myelin basic protein (BP) could play a central role. T cells specific for BP were cloned from the blood of multiple sclerosis patients and normal individuals, and expression of T-cell receptor variable region genes was analyzed. A remarkable bias for use of beta-chain variable region (V beta) 5.2 and, to a lesser extent, V beta 6.1 was...
Topics
- Base Sequence
- CD4 Antigens
- Clone Cells
- Genes
- Genetic Variation
- Humans
- Molecular Sequence Data
- Multiple Sclerosis
- Myelin Basic Protein
- Oligodeoxyribonucleotides