Article
Biased T cell receptor V gene usage in rheumatoid arthritis. Oligoclonal expansion of T cells expressing V alpha 2 genes in synovial fluid but not in peripheral blood.
Arthritis and rheumatism - 1 Sept 1993
Bröker B M, Korthäuer U, Heppt P, Weseloh G, de la Camp R, Kroczek R A, Emmrich F
Abstract excerpt
OBJECTIVE: To analyze the T cell receptor (TCR) variable (V) region gene usage in the rheumatoid joint. METHODS: Monoclonal antibodies (MAb) were used to determine the prevalence of selected V elements on T cells in synovial fluid (SF) from rheumatoid arthritis (RA) patients and in peripheral blo...
Topics
- Adult
- Aged
- Arthritis, Rheumatoid
- Blood Cells
- Female
- Gene Expression
- Humans
- Immunoglobulin Variable Region
- Male
- Middle Aged
- Phenotype
- Receptors, Antigen, T-Cell, alpha-beta
- Synovial Fluid
- T-Lymphocytes