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Article

Restricted T-cell receptor V beta gene usage by myelin basic protein-specific T-cell clones in multiple sclerosis: predominant genes vary in individuals.

Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 1991

Ben-Nun A, Liblau R S, Cohen L, Lehmann D, Tournier-Lasserve E, Rosenzweig A, Zhang J W, Raus J C, Bach M A

Abstract excerpt

Recent studies in experimental autoimmune encephalomyelitis as a model for multiple sclerosis (MS) have demonstrated limited heterogeneity in T-cell antigen receptors (TCR) specific for myelin basic protein (MBP). To investigate restricted beta-chain variable-region (V beta) gene usage in humans, we analyzed TCR gene rearrangements in two lines and 34 MBP-specific T-cell clones that were isolated from five MS...

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Identifiers

PMID: 1706524
DOI: 10.1073/pnas.88.6.2466
PMCID: PMC51253

Genes

MBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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