Article
Restricted T-cell receptor V beta gene usage by myelin basic protein-specific T-cell clones in multiple sclerosis: predominant genes vary in individuals.
Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 1991
Ben-Nun A, Liblau R S, Cohen L, Lehmann D, Tournier-Lasserve E, Rosenzweig A, Zhang J W, Raus J C, Bach M A
Abstract excerpt
Recent studies in experimental autoimmune encephalomyelitis as a model for multiple sclerosis (MS) have demonstrated limited heterogeneity in T-cell antigen receptors (TCR) specific for myelin basic protein (MBP). To investigate restricted beta-chain variable-region (V beta) gene usage in humans,...
Topics
- Base Sequence
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- Genetic Variation
- Humans
- Molecular Sequence Data
- Multigene Family
- Multiple Sclerosis
- Myelin Basic Protein
- Oligonucleotide Probes
- Polymerase Chain Reaction
- Receptors, Antigen, T-Cell
- T-Lymphocytes