Article
The T-cell response to myelin basic protein in familial multiple sclerosis: diversity of fine specificity, restricting elements, and T-cell receptor usage.
Annals of neurology - 1 Sept 1993
Joshi N, Usuku K, Hauser S L
Abstract excerpt
Indirect evidence suggests that an autoimmune response to myelin basic protein (MBP) may be involved in the pathogenesis of multiple sclerosis (MS). In MS, several reports have suggested that restricted T-cell populations respond to MPB, as in inbred rodents with the MS disease model experimental allergic encephalomyelitis. In experimental allergic encephalomyelitis, the T-cell repertoire to MBP varies between...
Topics
- Alleles
- Cell Line
- Cells, Cultured
- Female
- HLA-D Antigens
- Haplotypes
- Humans
- Major Histocompatibility Complex
- Male
- Multiple Sclerosis
- Myelin Basic Protein