Common T-cell receptor V beta usage in oligoclonal T lymphocytes derived from cerebrospinal fluid and blood of patients with multiple sclerosis.

doi:10.1002/ana.410290109

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Article

Common T-cell receptor V beta usage in oligoclonal T lymphocytes derived from cerebrospinal fluid and blood of patients with multiple sclerosis.

Annals of neurology - 1 Jan 1991

Lee S J, Wucherpfennig K W, Brod S A, Benjamin D, Weiner H L, Hafler D A

Abstract excerpt

T-cell populations were investigated in the blood and cerebrospinal fluid of patients with multiple sclerosis and other neurological diseases. Individual T cells were directly cloned from the cerebrospinal fluid and blood before in vitro expansion, and their clonotypes were compared by Southern blot analysis of the rearrangement patterns of their T-cell receptor beta chain and gamma chain genes. This allowed the...

Topics

Adolescent
Adult
Aged
Base Sequence
Blotting, Southern
Child, Preschool
Clone Cells
DNA Probes
Female
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Middle Aged

Molecular Sequence Data

Multiple Sclerosis

Phenotype

Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 1847614
DOI: 10.1002/ana.410290109

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1847614-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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