Article
Selection for T-cell receptor V beta-D beta-J beta gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis.
Nature - 4 Mar 1993
Oksenberg J R, Panzara M A, Begovich A B, Mitchell D, Erlich H A, Murray R S, Shimonkevitz R, Sherritt M, Rothbard J, Bernard C C, Steinman L
Abstract excerpt
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system in which a restricted cellular immune response has been observed. In order to establish whether such T cell responses are likely to be antigen-specific particularly with regard to myelin basic protein (MBP), we analysed T-cell receptor (TCR) gene rearrangements directly from MS brain plaques, using the polymerase chain...
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