Article
Selection for T-cell receptor V beta-D beta-J beta gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis.
Nature - 4 Mar 1993
Oksenberg J R, Panzara M A, Begovich A B, Mitchell D, Erlich H A, Murray R S, Shimonkevitz R, Sherritt M, Rothbard J, Bernard C C, Steinman L
Abstract excerpt
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system in which a restricted cellular immune response has been observed. In order to establish whether such T cell responses are likely to be antigen-specific particularly with regard to myelin basic protein (...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Brain
- CD3 Complex
- Cloning, Molecular
- Encephalomyelitis, Autoimmune, Experimental
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- HLA-D Antigens
- Humans
- Molecular Sequence Data
- Multiple Sclerosis
- Myelin Basic Protein