Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

T cell receptor V beta gene usage in the recognition of myelin basic protein by cerebrospinal fluid- and blood-derived T cells from patients with multiple sclerosis.

Journal of neuroscience research - 1 Feb 1994

Chou Y K, Buenafe A C, Dedrick R, Morrison W J, Bourdette D N, Whitham R, Atherton J, Lane J, Spoor E, Hashim G A

Abstract excerpt

Because of its proximity to the central nervous system, the cerebrospinal fluid (CSF) represents an important source of T cells that potentially could mediate putative autoimmune diseases such as multiple sclerosis (MS). To overcome the low CSF cellularity, we evaluated culture conditions that co...

Topics

Adult
Aged
Base Sequence
Cell Division
Chronic Disease
Female
Gene Expression Regulation
Humans
Male
Middle Aged
Molecular Sequence Data
Multiple Sclerosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myelin Basic Protein

Phenotype

Polymerase Chain Reaction

Receptors, Antigen, T-Cell, alpha-beta

Recurrence

Source

Identifiers

PMID: 7512148
DOI: 10.1002/jnr.490370203

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7512148-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

T cell receptor V beta gene usage in the recognition of myelin basic protein by cerebrospinal fluid- and blood-derived T cells from patients with multiple sclerosis.PMID 7512148Read ↗

Preferential T-cell receptor beta-chain variable gene use in myelin basic protein-reactive T-cell clones from patients with multiple sclerosis.Semantic proximity Read ↗

Detailed Characterization of T Cell Receptor Repertoires in Multiple Sclerosis Brain LesionsSemantic proximity Read ↗

Oligoclonal expansion of memory CD8+ T cells in cerebrospinal fluid from multiple sclerosis patientsSemantic proximity Read ↗

Restricted T-cell receptor V beta gene usage by myelin basic protein-specific T-cell clones in multiple sclerosis: predominant genes vary in individuals.Semantic proximity Read ↗

Blood T-cell receptor chain transcriptome in multiple sclerosis. Characterization of the T cells with altered CDR3 length distributionSemantic proximity Read ↗

Common T-cell receptor V beta usage in oligoclonal T lymphocytes derived from cerebrospinal fluid and blood of patients with multiple sclerosis.Semantic proximity Read ↗

A complex role of herpes viruses in the disease process of multiple sclerosis.Semantic proximity Read ↗

Broader Epstein–Barr virus–specific T cell receptor repertoire in patients with multiple sclerosisSemantic proximity Read ↗

Multiple sclerosis: Brain-infiltrating CD8 <sup>+</sup> T cells persist as clonal expansions in the cerebrospinal fluid and bloodSemantic proximity Read ↗

Selection for T-cell receptor V beta-D beta-J beta gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis.Semantic proximity Read ↗

Biased T cell receptor V gene usage in rheumatoid arthritis. Oligoclonal expansion of T cells expressing V alpha 2 genes in synovial fluid but not in peripheral blood.Semantic proximity Read ↗

Single-Cell Repertoire Analysis Demonstrates that Clonal Expansion Is a Prominent Feature of the B Cell Response in Multiple Sclerosis Cerebrospinal FluidSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.