Individual specific bias usage of HLA-DR antigens in the restriction of myelin basic protein-reactive T cell clones.

doi:10.1016/0022-510x(93)90164-t

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Article

Individual specific bias usage of HLA-DR antigens in the restriction of myelin basic protein-reactive T cell clones.

Journal of the neurological sciences - 1 Jul 1993

Rohowsky-Kochan C, Eiman D, Cook S D

Abstract excerpt

Multiple sclerosis, a demyelinating disease of the human central nervous system occurs in genetically susceptible individuals through a presumably autoimmune mechanism directed against the myelin sheath. The influence of the major histocompatibility locus on T cell recognition of myelin basic pro...

Topics

Adult
Alleles
Autoantigens
CD4-Positive T-Lymphocytes
Cell Line
Clone Cells
Female
HLA-DR Antigens
Humans
Immunodominant Epitopes
Interferon-gamma
Male
Multiple Sclerosis
Myelin Basic Protein
T-Lymphocyte Subsets

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