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Article

Individual specific bias usage of HLA-DR antigens in the restriction of myelin basic protein-reactive T cell clones.

Journal of the neurological sciences - 1 Jul 1993

Rohowsky-Kochan C, Eiman D, Cook S D

Abstract excerpt

Multiple sclerosis, a demyelinating disease of the human central nervous system occurs in genetically susceptible individuals through a presumably autoimmune mechanism directed against the myelin sheath. The influence of the major histocompatibility locus on T cell recognition of myelin basic protein (MBP), a suspected target autoantigen, was investigated by analyzing MBP-specific T cell clones generated from the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 7691992
DOI: 10.1016/0022-510x(93)90164-t

Genes

MBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Individual specific bias usage of HLA-DR antigens in the restriction of myelin basic protein-reactive T cell clones.PMID 7691992Read ↗

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Preferential peptide specificity and HLA restriction of myelin basic protein-specific T cell clones derived from MS patients.Semantic proximity Read ↗

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Restricted T-cell receptor V beta gene usage by myelin basic protein-specific T-cell clones in multiple sclerosis: predominant genes vary in individuals.Semantic proximity Read ↗

Genetic control of pathogenic mechanisms in autoimmune demyelinating disease.Semantic proximity Read ↗

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