Article
A systematic assessment of common genetic variation in CYP11A and risk of breast cancer.
Cancer research - 15 Dec 2006
Setiawan Veronica Wendy, Cheng Iona, Stram Daniel O, Giorgi Elena, Pike Malcolm C, Van Den Berg David, Pooler Loreall, Burtt Noel P, Le Marchand Loic, Altshuler David, Hirschhorn Joel, Henderson Brian E, Haiman Christopher A
Abstract excerpt
CYP11A catalyzes the rate-limiting step in the biosynthesis of sex-steroid hormones. In this study, we employed a systematic approach that involved gene resequencing and a haplotype-based analysis to investigate the relationship between common variation in CYP11A and breast cancer risk among African-Americans, Latinas, Japanese-Americans, Native Hawaiians, and Whites in the Multiethnic Cohort Study. Resequencing...
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