Article
Common variation in BRCA2 and breast cancer risk: a haplotype-based analysis in the Multiethnic Cohort.
Human molecular genetics - 15 Oct 2004
Freedman Matthew L, Penney Kathryn L, Stram Daniel O, Le Marchand Loïc, Hirschhorn Joel N, Kolonel Laurence N, Altshuler David, Henderson Brian E, Haiman Christopher A
Abstract excerpt
It is well established that rare mutations in BRCA2 predispose to familial breast cancer, but whether common variants at this locus contribute more modest risk to sporadic breast cancer has not been thoroughly investigated. We performed a haplotype-based study of BRCA2 among women in the Multiethnic Cohort Study (MEC), genotyping 50 SNPs spanning 109.4 kb of the BRCA2 gene. Twenty-one haplotype-tagging SNPs...
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