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Article

A comprehensive haplotype analysis of CYP19 and breast cancer risk: the Multiethnic Cohort.

Human molecular genetics - 15 Oct 2003

Haiman Christopher A, Stram Daniel O, Pike Malcolm C, Kolonel Laurence N, Burtt Noel P, Altshuler David, Hirschhorn Joel, Henderson Brian E

Abstract excerpt

The CYP19 gene encodes for aromatase (P450arom), a key steroidogenic enzyme that catalyzes the final step of estrogen biosynthesis. Apart from rare mutations in CYP19 which result in severe phenotypes associated with estrogen insufficiency, little is known about whether common variation in CYP19 is associated with risk of hormone-related diseases. In this study, we employed a haplotype-based approach to search...

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PMID: 12944421
DOI: 10.1093/hmg/ddg294

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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