Article
Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort.
BMC cancer - 30 Jan 2009
Haiman Christopher A, Garcia Rachel R, Hsu Chris, Xia Lucy, Ha Helen, Sheng Xin, Le Marchand Loic, Kolonel Laurence N, Henderson Brian E, Stallcup Michael R, Greene Geoffrey L, Press Michael F
Abstract excerpt
BACKGROUND: Only a limited number of studies have performed comprehensive investigations of coding variation in relation to breast cancer risk. Given the established role of estrogens in breast cancer, we hypothesized that coding variation in steroid receptor coactivator and corepressor genes may alter inter-individual response to estrogen and serve as markers of breast cancer risk. METHODS: We sequenced the...
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