Article
Risk-association of CYP11A1 polymorphisms and breast cancer among Han Chinese women in Southern China.
International journal of molecular sciences - 1 Jan 2012
Sun Minying, Yang Xuexi, Ye Changsheng, Xu Weiwen, Yao Guangyu, Chen Jun, Li Ming
Abstract excerpt
Exposure to endogenous sex hormones has been reported as a risk factor for breast cancer. The CYP11A1 gene encodes the key enzyme that catalyzes the initial and rate-limiting step in steroid hormone synthesis. In this study, the associations between single nucleotide polymorphisms (SNPs) in CYP11A1 and breast cancer susceptibility were examined. Six SNPs in CYP11A1 were genotyped using the MassARRAY IPLEX...
Topics
- Adult
- Aged
- Aged, 80 and over
- Asian People
- Breast Neoplasms
- Case-Control Studies
- China
- Cholesterol Side-Chain Cleavage Enzyme
- Ethnicity
- Female
- Genetic Association Studies