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Article

Genome-Wide Analysis of Rare Haplotypes Associated with Breast Cancer Risk.

Cancer research - 18 Jan 2023

Wang Fan, Moon Wonjong, Letsou William, Sapkota Yadav, Wang Zhaoming, Im Cindy, Baedke Jessica L, Robison Leslie, Yasui Yutaka

Abstract excerpt

Numerous common genetic variants have been linked to breast cancer risk, but they only partially explain the total breast cancer heritability. Inference from Nordic population-based twin data indicates rare high-risk loci as the chief determinant of breast cancer risk. Here, we use haplotypes, rather than single variants, to identify rare high-risk loci for breast cancer. With computationally phased genotypes...

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Identifiers

PMID: 36354368
DOI: 10.1158/0008-5472.CAN-22-1888
PMCID: PMC9852031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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