Article
Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women.
Cancer research - 1 Mar 2007
Haiman Christopher A, Dossus Laure, Setiawan V Wendy, Stram Daniel O, Dunning Alison M, Thomas Gilles, Thun Michael J, Albanes Demetrius, Altshuler David, Ardanaz Eva, Boeing Heiner, Buring Julie, Burtt Noël, Calle Eugenia E, Chanock Stephen, Clavel-Chapelon Françoise, Colditz Graham A, Cox David G, Feigelson Heather Spencer, Hankinson Susan E, Hayes Richard B, Henderson Brian E, Hirschhorn Joel N, Hoover Robert, Hunter David J, Kaaks Rudolf, Kolonel Laurence N, Le Marchand Loïc, Lenner Per, Lund Eiliv, Panico Salvatore, Peeters Petra H, Pike Malcolm C, Riboli Elio, Tjonneland Anne, Travis Ruth, Trichopoulos Dimitrios, Wacholder Sholom, Ziegler Regina G
Abstract excerpt
The CYP19A1 gene encodes the enzyme aromatase, which is responsible for the final step in the biosynthesis of estrogens. In this study, we used a systematic two-step approach that included gene resequencing and a haplotype-based analysis to comprehensively survey common genetic variation across the CYP19A1 locus in relation to circulating postmenopausal steroid hormone levels and breast cancer risk. This study...
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