Haplotype analysis of the HSD17B1 gene and risk of breast cancer: a comprehensive approach to multicenter analyses of prospective cohort studies.

doi:10.1158/0008-5472.CAN-05-3574

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Article

Haplotype analysis of the HSD17B1 gene and risk of breast cancer: a comprehensive approach to multicenter analyses of prospective cohort studies.

Cancer research - 15 Feb 2006

Feigelson Heather Spencer, Cox David G, Cann Howard M, Wacholder Sholom, Kaaks Rudolf, Henderson Brian E, Albanes Demetrius, Altshuler David, Berglund Goran, Berrino Franco, Bingham Sheila, Buring Julie E, Burtt Noel P, Calle Eugenia E, Chanock Stephen J, Clavel-Chapelon Francoise, Colditz Graham, Diver W Ryan, Freedman Matthew L, Haiman Christopher A, Hankinson Susan E, Hayes Richard B, Hirschhorn Joel N, Hunter David, Kolonel Laurence N, Kraft Peter, LeMarchand Loic, Linseisen Jakob, Modi William, Navarro Carmen, Peeters Petra H, Pike Malcolm C, Riboli Elio, Setiawan V Wendy, Stram Daniel O, Thomas Gilles, Thun Michael J, Tjonneland Anne, Trichopoulos Dimitrios

Abstract excerpt

The 17beta-hydroxysteroid dehydrogenase 1 gene (HSD17B1) encodes 17HSD1, which catalyzes the final step of estradiol biosynthesis. Despite the important role of HSD17B1 in hormone metabolism, few epidemiologic studies of HSD17B1 and breast cancer have been conducted. This study includes 5,370 breast cancer cases and 7,480 matched controls from five large cohorts in the Breast and Prostate Cancer Cohort...

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PMID: 16489054
DOI: 10.1158/0008-5472.CAN-05-3574

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