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A haplotype-based case-control study of BRCA1 and sporadic breast cancer risk.

Cancer research - 15 Aug 2005

Freedman Matthew L, Penney Kathryn L, Stram Daniel O, Riley Stephanie, McKean-Cowdin Roberta, Le Marchand Loïc, Altshuler David, Haiman Christopher A

Abstract excerpt

Rare, highly penetrant germ line mutations in BRCA1 strongly predispose women to a familial form of breast and ovarian cancer. Whether common variants (either coding or noncoding) at this locus contribute to the more common form of the disease is not yet known. We tested common variation across the BRCA1 locus in African American, Native Hawaiian, Japanese, Latino, and White women in the Multiethnic Cohort Study....

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Source

Identifiers

PMID: 16103107
DOI: 10.1158/0008-5472.CAN-05-0132

Genes

BRCA1

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Source receipt: pubmed, retrieved 7 Sept 2026.

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