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Article

Haplotype analysis of CYP11A1 identifies promoter variants associated with breast cancer risk.

Cancer research - 15 Jun 2007

Yaspan Brian L, Breyer Joan P, Cai Qiuyin, Dai Qi, Elmore J Bradford, Amundson Isaac, Bradley Kevin M, Shu Xiao-Ou, Gao Yu-Tang, Dupont William D, Zheng Wei, Smith Jeffrey R

Abstract excerpt

The CYP11A1 gene encodes the cholesterol side chain cleavage enzyme that catalyzes the initial and rate-limiting step of steroidogenesis. A large number of epidemiologic studies have implicated the duration and degree of endogenous estrogen exposure in the development of breast cancer in women. Here, we conduct a systematic investigation of the role of genetic variation of the CYP11A1 gene in breast cancer risk...

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Identifiers

PMID: 17575134
DOI: 10.1158/0008-5472.CAN-07-0467
PMCID: PMC2805128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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