Article

Genome-wide Analysis of Rare Haplotypes Associated with Breast Cancer Risk: Discovery, Replication, and Generalizability Evaluation

2022-10-22

Abstract excerpt

While numerous common variants have been linked to breast cancer (BCa) risk, they explain only partially the total BCa heritability. Inference from the Nordic population-based twin data indicates that rare high-risk loci are the chief determinant of BCa risk. Here, we use haplotypes, rather than single variants, to identify rare high-risk loci for BCa. With computationally phased genotypes from 181,034 white Briti...

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Literature Corpus work: 8b7881ec-6de3-5a4d-ac2b-abec181a503b
DOI: 10.1101/2022.10.21.22281360

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