Article
Ethnic differences in the distribution of CYP3A5 gene polymorphisms.
Xenobiotica; the fate of foreign compounds in biological systems - 1 Dec 2006
Quaranta S, Chevalier D, Allorge D, Lo-Guidice J M, Migot-Nabias F, Kenani A, Imbenotte M, Broly F, Lacarelle B, Lhermitte M
Abstract excerpt
The genetic polymorphism affecting the CYP3A5 enzyme is responsible for interindividual and interethnic variability in the metabolism of CYP3A5 substrates. The full extent of the CYP3A5 genetic polymorphism was analysed in French Caucasian, Gabonese and Tunisian populations using a polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) strategy. In the three populations, eight, 17 and ten...
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