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Article

Genetic variability in CYP3A5 and its possible consequences.

Pharmacogenomics - 1 Apr 2004

Xie Hong-Guang, Wood Alastair J J, Kim Richard B, Stein C Michael, Wilkinson Grant R

Abstract excerpt

The cytochrome P450 3A (CYP3A) subfamily members are the most abundant and important drug-metabolizing enzymes in humans, and wide interindividual variability in CYP3A expression and function is present. CYP3A4 alone cannot fully explain the observed constitutive variability because its genetic variants are relatively uncommon and have limited functional significance, whereas CYP3A5 expression in humans is highly...

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Identifiers

PMID: 15102541
DOI: 10.1517/phgs.5.3.243.29833

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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