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A study on the genetic polymorphisms of CYP3A5 among the Orang Asli in Malaysia using a next generation sequencing platform.

Annals of human biology - 1 Mar 2018

Ang Geik Yong, Yu Choo Yee, Johari James Richard, Ahmad Aminuddin, Abdul Rahman Thuhairah, Mohd Nor Fadzilah, Shaari Syahrul Azlin, Ismail Adzrool Idzwan, Teh Lay Kek, Salleh Mohd Zaki

Abstract excerpt

BACKGROUND: CYP3A5 is the predominant sub-family of biotransformation enzymes in the liver and the genetic variations in CYP3A5 are an important determinant of inter-individual and inter-ethnic differences in CYP3A-mediated drug disposition and response. AIM: This study aims to investigate the genetic polymorphisms of CYP3A5 among the Orang Asli in Peninsular Malaysia using a next generation sequencing platform....

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Cytochrome P-450 CYP3A
Ethnicity
Gene Frequency
Genotype
High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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PMID: 29447003
DOI: 10.1080/03014460.2018.1440004

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