Article
Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression.
Nature genetics - 1 Apr 2001
Kuehl P, Zhang J, Lin Y, Lamba J, Assem M, Schuetz J, Watkins P B, Daly A, Wrighton S A, Hall S D, Maurel P, Relling M, Brimer C, Yasuda K, Venkataramanan R, Strom S, Thummel K, Boguski M S, Schuetz E
Abstract excerpt
Variation in the CYP3A enzymes, which act in drug metabolism, influences circulating steroid levels and responses to half of all oxidatively metabolized drugs. CYP3A activity is the sum activity of the family of CYP3A genes, including CYP3A5, which is polymorphically expressed at high levels in a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.