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Distribution of CYP3A4 and CYP3A5 Polymorphisms and Genotype Combination Implicated in Tacrolimus Metabolism.

La Tunisie medicale - 5 Sept 2024

Hannachi Ibtissem, Chadli Zohra, Kerkeni Emna, Chaabane Amel, Ben-Fredj Nadia, A Boughattas Naceur, Aouam Karim

Abstract excerpt

INTRODUCTION: Human cytochrome P450 (CYP), particularly CYP3A4 and CYP3A5 is mainly responsible for the metabolism of several drugs including tacrolimus. Significant interracial/interethnic variation in the expression and function of CYP3A5 and CYP3A4 is caused by Single Nucleotide Polymorphisms (SNPs) of genes encoding these proteins. AIM: The present study investigated the genetic polymorphisms CYP3A4*1B,...

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Case-Control Studies
Cytochrome P-450 CYP3A
Gene Frequency
Immunosuppressive Agents
Kidney Transplantation

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PMID: 39287345
DOI: 10.62438/tunismed.v102i9.4969
PMCID: PMC11450750

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