Article
CYP2A13 genetic polymorphism in French Caucasian, Gabonese and Tunisian populations.
Xenobiotica; the fate of foreign compounds in biological systems - 1 Jul 2005
Cauffiez C, Pottier N, Tournel G, Lo-Guidice J-M, Allorge D, Chevalier D, Migot-Nabias F, Kenani A, Broly F
Abstract excerpt
Since human CYP2A13 is expressed in the respiratory tract and is involved in the activation of tobacco-specific nitrosamines, some of the previously reported sequence variations may contribute to inter-individual and inter-ethnic differences in the susceptibility of tobacco-related tumorigenesis. The aim was to compare the frequencies of the 578C > T (Arg101Stop), 3375C > T (Arg257Cys) and 7520C > G...
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