Article
Genetic variability of CYP2D6, CYP3A4 and CYP3A5 among the Egyptian population.
Pharmacogenomics - 1 Apr 2021
Mutawi Thuraya M, Zedan Mohamed M, Yahya Raida S, Zakria Mahmoud M, El-Sawi Mamdouh R, Gaedigk Andrea
Abstract excerpt
Aim: This study investigated major allelic variants of CYP2D6, CYP3A4 and CYP3A5 in Egyptians, an Arabic population for which there is little information regarding these important pharmacogenes. Patients & methods:CYP2D6*2, *4, *5, *10, *41 and gene copy number variation, as well as CYP3A4*22 and CYP3A5*3 were determined with commercially available TaqMan assays in 145 healthy study participants. Results: The...
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