Article
Distribution of Genetic Polymorphisms of Genes Implicated in Thiopurine Drugs Metabolism.
Therapeutic drug monitoring - 1 Oct 2018
Chadli Zohra, Kerkeni Emna, Hannachi Ibtissem, Chouchene Saoussen, Ben Fredj Nadia, Boughattas Naceur A, Aouam Karim, Chaabane Amel
Abstract excerpt
Thiopurine-S-methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) are crucial enzymes involved in the metabolism of thiopurine drugs. Significant interethnic variation in the expression of TPMT and ITPA is caused by single nucleotide polymorphisms of genes encoding these proteins. The aim of this study was to describe the distribution of TPMT and ITPA polymorphisms in healthy Tunisian subjects...
Topics
- Adolescent
- Adult
- Black People
- Drug Hypersensitivity
- Female
- Gene Frequency
- Genotype
- Humans
- Male
- Methyltransferases
- Middle Aged
- Polymorphism, Single Nucleotide
- Purine-Pyrimidine Metabolism, Inborn Errors
- Purines