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Article

Genomic DNA pooling for whole-genome association scans in complex disease: empirical demonstration of efficacy in rheumatoid arthritis.

Genes and immunity - 1 Jan 2007

Steer S, Abkevich V, Gutin A, Cordell H J, Gendall K L, Merriman M E, Rodger R A, Rowley K A, Chapman P, Gow P, Harrison A A, Highton J, Jones P B B, O'Donnell J, Stamp L, Fitzgerald L, Iliev D, Kouzmine A, Tran T, Skolnick M H, Timms K M, Lanchbury J S, Merriman T R

Abstract excerpt

A pragmatic approach that balances the benefit of a whole-genome association (WGA) experiment against the cost of individual genotyping is to use pooled genomic DNA samples. We aimed to determine the feasibility of this approach in a WGA scan in rheumatoid arthritis (RA) using the validated human leucocyte antigen (HLA) and PTPN22 associations as test loci. A total of 203 269 single-nucleotide polymorphisms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

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Source

Identifiers

PMID: 17159887
DOI: 10.1038/sj.gene.6364359

Genes

PTPN22
MAGI3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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