Article
A large-scale rheumatoid arthritis genetic study identifies association at chromosome 9q33.2.
PLoS genetics - 27 Jun 2008
Chang Monica, Rowland Charles M, Garcia Veronica E, Schrodi Steven J, Catanese Joseph J, van der Helm-van Mil Annette H M, Ardlie Kristin G, Amos Christopher I, Criswell Lindsey A, Kastner Daniel L, Gregersen Peter K, Kurreeman Fina A S, Toes Rene E M, Huizinga Tom W J, Seldin Michael F, Begovich Ann B
Abstract excerpt
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease affecting both joints and extra-articular tissues. Although some genetic risk factors for RA are well-established, most notably HLA-DRB1 and PTPN22, these markers do not fully account for the observed heritability. To identify additional susceptibility loci, we carried out a multi-tiered, case-control association study, genotyping 25,966 putative...
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