Article
Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scans.
Human genetics - 1 Apr 2009
Bossé Yohan, Bacot François, Montpetit Alexandre, Rung Johan, Qu Hui-Qi, Engert James C, Polychronakos Constantin, Hudson Thomas J, Froguel Philippe, Sladek Robert, Desrosiers Martin
Abstract excerpt
The success of genome-wide association studies (GWAS) to identify risk loci of complex diseases is now well-established. One persistent major hurdle is the cost of those studies, which make them beyond the reach of most research groups. Performing GWAS on pools of DNA samples may be an effective strategy to reduce the costs of these studies. In this study, we performed pooling-based GWAS with more than 550,000...
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