Article
A genomewide screen in multiplex rheumatoid arthritis families suggests genetic overlap with other autoimmune diseases.
American journal of human genetics - 1 Apr 2001
Jawaheer D, Seldin M F, Amos C I, Chen W V, Shigeta R, Monteiro J, Kern M, Criswell L A, Albani S, Nelson J L, Clegg D O, Pope R, Schroeder H W, Bridges S L, Pisetsky D S, Ward R, Kastner D L, Wilder R L, Pincus T, Callahan L F, Flemming D, Wener M H, Gregersen P K
Abstract excerpt
Rheumatoid arthritis (RA) is an autoimmune/inflammatory disorder with a complex genetic component. We report the first major genomewide screen of multiplex families with RA gathered in the United States. The North American Rheumatoid Arthritis Consortium, using well-defined clinical criteria, has collected 257 families containing 301 affected sibling pairs with RA. A genome screen for allele sharing was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.