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Article

Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase.

The EMBO journal - 1 Sept 1991

Reith A D, Ellis C, Lyman S D, Anderson D M, Williams D E, Bernstein A, Pawson T

Abstract excerpt

Germline mutations at the Dominant White Spotting (W) and Steel (Sl) loci have provided conclusive genetic evidence that c-kit mediated signal transduction pathways are essential for normal mouse development. We have analysed the interactions of normal and mutant W/c-kit gene products with cytoplasmic signalling proteins, using transient c-kit expression assays in COS cells. In addition to the previously...

Topics

1-Phosphatidylinositol 4-Kinase
Amino Acid Sequence
Animals
Base Sequence
Blotting, Western
Cell Line, Transformed
Electrophoresis, Polyacrylamide Gel
GTPase-Activating Proteins
Gene Expression
Mast Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Molecular Sequence Data

Mutation

Phosphorylation

Phosphotransferases

Plasmids

Precipitin Tests

Protein-Tyrosine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 1714377
DOI: 10.1002/j.1460-2075.1991.tb07784.x
PMCID: PMC452940

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1714377-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase.PMID 1714377Read ↗

The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor.Semantic proximity Read ↗

Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W.Semantic proximity Read ↗

The dominant W42 spotting phenotype results from a missense mutation in the c-kit receptor kinase.Semantic proximity Read ↗

Expression of functional c-kit receptors rescues the genetic defect of W mutant mast cells.Semantic proximity Read ↗

W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor.Semantic proximity Read ↗

Steel factor and c-kit protooncogene: genetic lessons in signal transduction.Semantic proximity Read ↗

Differential effects of W mutations on p145c-kit tyrosine kinase activity and substrate interaction.Semantic proximity Read ↗

The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis.Semantic proximity Read ↗

Ectopic expression of a c-kitW42 minigene in transgenic mice: recapitulation of W phenotypes and evidence for c-kit function in melanoblast progenitors.Semantic proximity Read ↗

Long-range genomic rearrangements upstream of Kit dysregulate the developmental pattern of Kit expression in W57 and Wbanded mice and interfere with distinct steps in melanocyte development.Semantic proximity Read ↗

Exon skipping by mutation of an authentic splice site of c-kit gene in W/W mouse.Semantic proximity Read ↗

W-sash affects positive and negative elements controlling c-kit expression: ectopic c-kit expression at sites of kit-ligand expression affects melanogenesis.Semantic proximity Read ↗

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