Article
Exon skipping by mutation of an authentic splice site of c-kit gene in W/W mouse.
Nucleic acids research - 25 Mar 1991
Hayashi S, Kunisada T, Ogawa M, Yamaguchi K, Nishikawa S
Abstract excerpt
The murine mutation dominant white spotting (W) is in the proto-oncogene, c-kit. The receptor tyrosine kinase encoded by this gene has pleiotropic effects on murine development including hemopoietic cells, pigment cells, and germ cells. In this study, mutation in W homozygous mouse was identified as a single base substitution (GT----AT) at the 5'-splice donor site of the exon which encodes the transmembrane...
Topics
- Animals
- Base Sequence
- Blotting, Southern
- DNA
- Exons
- Mast Cells
- Mice
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins