Expression of functional c-kit receptors rescues the genetic defect of W mutant mast cells.

doi:10.1002/j.1460-2075.1991.tb04936.x

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Article

Expression of functional c-kit receptors rescues the genetic defect of W mutant mast cells.

The EMBO journal - 1 Dec 1991

Alexander W S, Lyman S D, Wagner E F

Abstract excerpt

Loss-of-function mutations in the gene for the c-kit tyrosine kinase receptor are strongly implicated in the developmental abnormalities of W mutant mice. To dissect further the relationship between kit and the W phenotype, retroviruses carrying the normal murine c-kit gene were constructed. In i...

Topics

3T3 Cells
Animals
Blotting, Northern
Genes, Viral
Mast Cells
Mice
Mutation
Phenotype
Pigmentation
Promoter Regions, Genetic
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-kit
RNA
Receptors, Cell Surface
Retroviridae
Thymidine Kinase
Transfection

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