Article
W-sash affects positive and negative elements controlling c-kit expression: ectopic c-kit expression at sites of kit-ligand expression affects melanogenesis.
Development (Cambridge, England) - 1 Jul 1993
Duttlinger R, Manova K, Chu T Y, Gyssler C, Zelenetz A D, Bachvarova R F, Besmer P
Abstract excerpt
The receptor tyrosine kinase c-kit and its cognate ligand KL are encoded at the white spotting (W) and steel (Sl) loci of the mouse, respectively. Mutations at both the W and the Sl locus cause deficiencies in gametogenesis, melanogenesis and hematopoiesis (erythrocytes and mast cells). The W-sash mutation differs from most W mutations in that it affects primarily mast cells and melanogenesis but not other...
Topics
- Animals
- Cells, Cultured
- DNA
- Gene Expression Regulation, Enzymologic
- Gestational Age
- Lung
- Mast Cells
- Melanins
- Melanocytes
- Mesoderm
- Mice