Article
Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W.
The EMBO journal - 1 Jun 1990
Nocka K, Tan J C, Chiu E, Chu T Y, Ray P, Traktman P, Besmer P
Abstract excerpt
The proto-oncogene c-kit encodes a transmembrane tyrosine protein kinase receptor for an unknown ligand and is allelic with the murine white-spotting locus (W). Mutations at the W locus affect various aspects of hematopoiesis, the proliferation and migration of primordial germ cells and melanobla...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Cells, Cultured
- Chromosome Mapping
- Fibroblasts
- Mast Cells
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Molecular Sequence Data
- Mutation
- Phenotype
- Pigmentation
- Protein-Tyrosine Kinases