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Article

Differential effects of W mutations on p145c-kit tyrosine kinase activity and substrate interaction.

The Journal of biological chemistry - 5 Jul 1992

Herbst R, Shearman M S, Obermeier A, Schlessinger J, Ullrich A

Abstract excerpt

The c-kit gene, mapped to the dominant white spotting (W) locus of the mouse (Chabot, B., Stephenson, D. A., Chapman, V. M., Besmer, P., and Bernstein, A. (1988) Nature 335, 88-89; Geissler, E. N., Ryan, M. A., and Housman, D. E. (1988) Cell 55, 185-192), encodes a receptor tyrosine kinase, p145c-kit. Germline mutations at the W locus lead to loss of function alterations in p145c-kit, and result in mice with...

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PMID: 1377679

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Differential effects of W mutations on p145c-kit tyrosine kinase activity and substrate interaction.PMID 1377679Read ↗

W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor.Semantic proximity Read ↗

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The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis.Semantic proximity Read ↗

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