Article
Differential effects of W mutations on p145c-kit tyrosine kinase activity and substrate interaction.
The Journal of biological chemistry - 5 Jul 1992
Herbst R, Shearman M S, Obermeier A, Schlessinger J, Ullrich A
Abstract excerpt
The c-kit gene, mapped to the dominant white spotting (W) locus of the mouse (Chabot, B., Stephenson, D. A., Chapman, V. M., Besmer, P., and Bernstein, A. (1988) Nature 335, 88-89; Geissler, E. N., Ryan, M. A., and Housman, D. E. (1988) Cell 55, 185-192), encodes a receptor tyrosine kinase, p145c...
Topics
- Amino Acid Sequence
- Base Sequence
- Blotting, Western
- Cells, Cultured
- Electrophoresis, Polyacrylamide Gel
- Epidermal Growth Factor
- Humans
- Methionine
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-kit
- Substrate Specificity