Article
The dominant W42 spotting phenotype results from a missense mutation in the c-kit receptor kinase.
Science (New York, N.Y.) - 12 Jan 1990
Tan J C, Nocka K, Ray P, Traktman P, Besmer P
Abstract excerpt
The murine white spotting locus (W) is allelic with the proto-oncogene c-kit, which encodes a transmembrane tyrosine protein kinase receptor for an unknown ligand. Mutations at the W locus affect various aspects of hematopoiesis and the proliferation and migration of primordial germ cells and melanoblasts during development to varying degrees of severity. The W42 mutation has a particularly severe effect in both...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.