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Article

Steel factor and c-kit protooncogene: genetic lessons in signal transduction.

Critical reviews in oncogenesis - 1 Jan 1994

Lev S, Blechman J M, Givol D, Yarden Y

Abstract excerpt

Despite extensive research on the molecular mechanisms of signal transduction by growth factors and their oncogenic receptor tyrosine kinases, the physiological relevance of these pathways, especially in mammals, remains largely unknown. A unique exception is the Steel factor (SLF) and its c-kit-encoded receptor, because many natural germ line mutations of both the ligand and the receptor exist in mice. The...

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Source

Identifiers

PMID: 7531500
DOI: 10.1615/critrevoncog.v5.i2-3.30

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Steel factor and c-kit protooncogene: genetic lessons in signal transduction.PMID 7531500Read ↗

The kit ligand encoded at the murine Steel locus: a pleiotropic growth and differentiation factor.Semantic proximity Read ↗

Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant.Semantic proximity Read ↗

The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis.Semantic proximity Read ↗

Characterization of the gene-product of the Steel locus.Semantic proximity Read ↗

The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor.Semantic proximity Read ↗

Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase.Semantic proximity Read ↗

The murine W/c-kit and Steel loci and the control of hematopoiesis.Semantic proximity Read ↗

Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2.Semantic proximity Read ↗

Mouse hematopoietic stem cells and the interaction of c-kit receptor and steel factor.Semantic proximity Read ↗

Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains.Semantic proximity Read ↗

The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus.Semantic proximity Read ↗

Stem Cell Factor Receptor/c-Kit: From Basic Science to Clinical ImplicationsSemantic proximity Read ↗

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