Steel factor and c-kit protooncogene: genetic lessons in signal transduction.

doi:10.1615/critrevoncog.v5.i2-3.30

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Article

Steel factor and c-kit protooncogene: genetic lessons in signal transduction.

Critical reviews in oncogenesis - 1 Jan 1994

Lev S, Blechman J M, Givol D, Yarden Y

Abstract excerpt

Despite extensive research on the molecular mechanisms of signal transduction by growth factors and their oncogenic receptor tyrosine kinases, the physiological relevance of these pathways, especially in mammals, remains largely unknown. A unique exception is the Steel factor (SLF) and its c-kit-...

Topics

Animals
Hematopoietic Cell Growth Factors
Humans
Mice
Mutation
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-kit
Receptor Protein-Tyrosine Kinases
Receptors, Colony-Stimulating Factor
Signal Transduction
Stem Cell Factor

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