Article
The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis.
Development (Cambridge, England). Supplement - 1 Jan 1993
Besmer P, Manova K, Duttlinger R, Huang E J, Packer A, Gyssler C, Bachvarova R F
Abstract excerpt
The c-kit receptor tyrosine kinase belongs to the PDGF/CSF-1/c-kit receptor subfamily. The kit-ligand, KL, also called steel factor, is synthesized from two alternatively spliced mRNAs as transmembrane proteins that can either be proteolytically cleaved to produce soluble forms of KL or can funct...
Topics
- Animals
- Female
- Gametogenesis
- Hematopoietic Cell Growth Factors
- Humans
- Male
- Mice
- Mutation
- Phenotype
- Pigmentation
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-kit
- Receptor Protein-Tyrosine Kinases
- Receptors, Colony-Stimulating Factor
- Signal Transduction
- Stem Cell Factor